RTGP RESEARCH TEAM FOR GERIATRIC PATHOLOGY. TOKYO METROPOLITAN INSTITUTE FOR GERIATRICS AND GERONTOLOGY

共同研究

• Single-cell RNA sequencing to detect age-associated genes that identify senescent cells in the liver of aged mice. Doshida Y, Hashimoto S, Iwabuchi S, Takino Y, Ishiwata T, Aigaki T, Ishigami A. Sci Rep. 2023 Aug 30;13(1):14186.

  https://www.nature.com/articles/s41598-023-41352-6

• Clinicopathological and molecular characteristics of gastric papillary adenocarcinoma. Arai T, Komatsu A, Kanazawa N, Nonaka K, Ishiwata T. Pathol Int. 2023 Aug;73(8):358-366.  https://pubmed.ncbi.nlm.nih.gov/37341602/

• mTOR pathway as a potential therapeutic target for cancer stem cells in canine mammary carcinoma. Michishita M, Ochiai K, Nakahira R, Azakami D, Machida Y, Nagashima T, Nakagawa T, Ishiwata T.Front Oncol. 2023 Jan 27;13:1100602. https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1100602/full

• Chromosomal analysis of clonally related B-cell lymphomas with discordant immunoglobulin light-chain restrictions at different anatomical sites
  Keisuke Nonaka, Morito Kurata, Moriaki Tachibana, Akiko Komatsu, Yuuki Shichi, Fujiya Gomi, Toshiyuki Ishiwata, Kou Miyamoto, Tomio Arai.  Pathol Int. 2022 Dec 12. doi: 10.1111/pin.13297. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36504427/

• Spatiotemporal changes of tissue glycans depending on localization in cardiac aging. Itakura Y, Hasegawa Y, Kikkawa Y, Murakami Y, Sugiura K, Nagai Okatani C, Sasaki N, Umemura M, Takahashi Y, Kimura T, Kuno A, Ishiwata T, Toyoda M. Regenerative Therapy 22 (2023) 68-78. https://www.sciencedirect.com/science/article/pii/S2352320422001316

• Telomere attrition in intraductal papillary mucinous neoplasms of the pancreas associated with carcinogenesis and aging. Atsushi Miki, Yoko Matsuda, Junko Aida, Jun Watanabe, Yukihiro Sanada, Yasunaru Sakuma, Alan K Lefor, Noriyoshi Fukushima, Naohiro Sata, Tomio Arai, Kaiyo Takubo, Toshiyuki Ishiwata. Pancreas. 2022 Jul 1;51(6):678-683.  https://pubmed.ncbi.nlm.nih.gov/36206470/

• PRC2-dependent regulation of ganglioside expression during dedifferentiation contributes to the proliferation and migration of vascular smooth muscle cells.  Norihiko Sasaki, Kazumi Hirano, Yoko Itakura, Toshiyuki Ishiwata, Masashi Toyoda. Front Cell Dev Biol. 2022 Oct 13;10:1003349.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606594/

• Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation. Yoshibumi Ueda, Yuri Miura, Nario Tomishige, Naotoshi Sugimoto, Megumi Murase, Genki Kawamura, Norihiko Sasaki, Toshiyuki Ishiwata, Takeaki Ozawa. Cell Chem Biol. 2022 Nov 17;29(11):1576-1587.e5. https://www.sciencedirect.com/science/article/pii/S2451945622003567?via%3Dihub

• Sphingomyelin localization in the intestinal crypt surface. Yoshibumi Ueda, Mitsuhiro Abe, Toshiyuki Ishiwata, Takeaki Ozawa. Biochem Biophys Res Commun. 2022 Apr 14;611:14-18. doi: 10.1016/j.bbrc.2022.03.128. Epub ahead of print. PMID: 35472605.　Sphingomyelin localization in the intestinal crypt surface – ScienceDirect

  (さらに…)

  MORE

• TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition. Norihiko Sasaki, Seiichi Shinji, Yuuki Shichi, Toshiyuki Ishiwata, Tomio Arai, Takeshi Yamada, Goro Takahashi, Ryo Ohta, Hiromichi Sonoda, Akihisa Matsuda, Takuma Iwai, Kohki Takeda, Kazuhide Yonaga, Koji Ueda, Sho Kuriyama, Toshimitsu Miyasaka, Hiroshi Yoshida. Biochem Biophys Rep. 2022 Mar 1;30:101239. doi: 10.1016/j.bbrep.2022.101239.

  (さらに…)

  MORE

• A New Anorectal Melanoma Cell Line Derived from a Primary Human Rectal Tumor. Seiichi Shinji, Yuuki Shichi, Takeshi Yamada, Goro Takahashi, Ryo Ohta, Hiromichi Sonoda, Akihisa Matsuda, Kazuhide Yonaga, Takuma Iwai, Kohki Takeda, Koji Ueda, Sho Kuriyama, Toshimitsu Miyasaka, Yoshibumi Ueda, Norihiko Sasaki, Kimimasa Takahashi, Ryuji Ohashi, Toshiyuki Ishiwata, Tomio Arai, Hiroshi Yoshida. J Nippon Med Sch. 2022 Aug27;89(4):368-376. doi: 10.1272/jnms.JNMS.2022_89-402.

  (さらに…)

  MORE

• Involvement of Nestin in the Progression of Canine Mammary Carcinoma. Hisashi Yoshimura, Maiko Moriya, Ayaka Yoshida, Masami Yamamoto, Yukino Machida, Kazuhiko Ochiai, Masaki Michishita, Takayuki Nakagawa, Yoko Matsuda, Kimimasa Takahashi, Shinji Kamiya, Toshiyuki Ishiwata. Vet Pathol. 2021 May 31;3009858211018656. doi: 10.1177/03009858211018656.

• Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19-9 expression occurring in elderly individuals: An autopsy study. Tan Wang, Yoko Matsuda, Keisuke Nonaka, Mototsune Kakizaki, Toshiyuki Ishiwata, Nobuo Kanazawa, Satoko Uegaki, Masaki Muramatsu, Motoji Sawabe, Seijiro Mori, Masashi Tanaka, Masanobu Kitagawa, Tomio Arai. Pathol Int. 2020 Feb;70(2):92-100. https://pubmed.ncbi.nlm.nih.gov/31867815/

• Expression and role of long non-coding RNA H19 in carcinogenesis. Yoshimura H, Matsuda Y, Yamamoto M, Kamiya S, Ishiwata T. Front Biosci (Landmark Ed). 2018 Jan 1;23:614-625. Review. PubMed PMID: 28930564.

  (さらに…)

  MORE

• Gastric high-grade dysplasia can be associated with submucosal invasion: evaluation of its prevalence in a series of 121 endoscopically resected specimens. Sakurai U, Lauwers GY, Vieth M, Sawabe M, Arai T, Yoshida T, Aida J, Takubo K.  Am J Surg Pathol 2014 Nov; 38(11):1545-50.

  (さらに…)

  MORE

• Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly: An autopsy study of 1,536 patients. Motoji Sawabe, Masashi Tanaka, Kouji Chida, Tomio Arai, Yutaka Nishigaki, Noriyuki Fuku, Makiko Naka Mieno, Aya Kuchiba, Noriko Tanaka.  J Atheroscler Thromb 2011; 18: 166-175.

  (さらに…)

  MORE

• Hypermethylation of hMLH1 promoter gene with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly. Tomio Arai, Yukiyoshi Esaki, Motoji Sawabe, Naoko Honma, Ken-ichi Nakamura, Kaiyo Takubo. Mod Pathol 2004; 17: 172-179.

  (さらに…)

  MORE