RTGP RESEARCH TEAM FOR GERIATRIC PATHOLOGY. TOKYO METROPOLITAN INSTITUTE FOR GERIATRICS AND GERONTOLOGY

がん幹細胞研究

• Multiple cystic sphere formation from PK-8 cells in three-dimensional culture. Shichi Y, Gomi F, Ueda Y, Nonaka K, Hasegawa F, Hasegawa Y, Hinata N, Yoshimura H, Yamamoto M, Takahashi K, Arai T, Ishiwata T. Biochemistry and Biophysics Reports 32　(2022) 101339

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• Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer Through H19 Long Non-Coding RNA Expression. Sasaki N, Hirano K, Shichi Y, Gomi F, Yoshimura H, Matsushita A, Toyoda M, Ishiwata T. Cancers 2022, 14(9), 2055. https://doi.org/10.3390/cancers14092055

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• Gangliosides as signal regulators in cancer. Norihiko Sasaki, Masashi Toyoda, Toshiyuki Ishiwata. International Journal of Molecular Sciences, 2021, 22 (10), 5076. https://www.mdpi.com/1422-0067/22/10/5076

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• Polyvinyl alcohol increased growth, migration, invasion, and sphere size in the PK-8 pancreatic ductal adenocarcinoma cell line. Fujiya Gomi, Norihiko Sasaki, Yuuki Shichi, Fuuka Minami, Seiichi Shinji, Masashi Toyoda, Toshiyuki Ishiwata. Heliyon 7 (2021) e06182. https://doi.org/10.1016/j.heliyon.2021.e06182 (さらに…)

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• FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer. Norihiko Sasaki N, Fujiya Gomi , Hisashi Yoshimura, Masami Yamamoto, Yoko Matsuda, Masaki Michishita, Hitoshi Hatakeyama, Yoichi Kawano, Masashi Toyoda, Murray Korc, Toshiyuki Ishiwata. Cancers (Basel). 2020 Oct 14;12(10):2976. doi: 10.3390/cancers12102976. PMID: 33066597. https://www.mdpi.com/2072-6694/12/10/2976

• Ganglioside GM2, highly expressed in the MIA PaCa-2 pancreatic ductal adenocarcinoma cell line, is correlated with growth, invasion, and advanced stage. Norihiko Sasaki, Kenichi Hirabayashi, Masaki Michishita, Kimimasa Takahashi, Fumio Hasegawa, Fujiya Gomi, Yoko Itakura, Naoya Nakamura, Masashi Toyoda, Toshiyuki Ishiwata.  Scientific Reports. 2019 Dec 18;9(1):19369. https://pubmed.ncbi.nlm.nih.gov/31852956/  (さらに…)

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• Enhanced morphological and functional differences of pancreatic cancer with epithelial or mesenchymal characteristics in 3D culture. Shichi Y, Sasaki N, Michishita M, Hasegawa F, Matsuda Y, Arai T, Gomi F, Aida F, Takubo T, Toyoda M, Yoshimura H, Takahashi K, Ishiwata T. Scientific  Reports. 2019 Jul 26;9(1):10871. doi:10.1038/s41598-019-47416-w. https://www.nature.com/articles/s41598-019-47416-w

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• Fetal bovine serum enlarges the size of human pancreatic cancer spheres accompanied by an increase in the expression of cancer stem cell markers. Norihiko Sasaki, Masashi Toyoda, Fumio Hasegawa, Masakazu Fujiwara, Fujiya Gomi, Toshiyuki Ishiwata. Biochem Biophys Res Commun. 2019 Jun 18; 514 (1): 112-117, https://pubmed.ncbi.nlm.nih.gov/31027735/

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• Comparison of functional glycans between cancer stem cells and normal stem cells. Sasaki N, Itakura Y, Gomi F, Hirano K, Toyoda M, Ishiwata T.  Histol Histopathol. 2019 Apr 26:18119. doi: 10.14670/HH-18-119.

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• Pancreatic cancer stem cells: features and detection methods. Toshiyuki Ishiwata, Yoko Matsuda, Hisashi Yoshimura, Norihiko Sasaki, Shunji Ishiwata, Noshi Ishikawa, Kaiyo Takubo, Tomio Arai, Junko Aida. Pathol Oncol Res. 2018 Oct;24(4):797-805. doi: 10.1007/s12253-018-0420-x. Epub 2018 Jun 8. Review. PubMed PMID: 29948612.

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• H19 long non-coding RNA contributes to sphere formation and invasion through regulation of CD24 and integrin expression in pancreatic cancer cells. Norihiko Sasaki, Masashi Toyoda, Hisashi Yoshimura, Yoko Matsuda, Tomio Arai, Kaiyo Takubo, Junko Aida, Toshiyuiki Ishiwata. Oncotarget. 2018 Oct 5;9(78):34719-34734. https://pubmed.ncbi.nlm.nih.gov/30410672/

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• Reduced expression of the H19 long non-coding RNA inhibits pancreatic cancer metastasis. Hisashi Yoshimura, Yoko Matsuda, Masami Yamamoto, Masaki Michishita, Kimimasa Takahashi, Norihiko Sasaki, Naoshi Ishikawa, Junko Aida, Kaiyo Takubo, Tomio Arai, Toshiyuki Ishiwata.Lab Invest. 2018 Jun;98(6):814-824. https://pubmed.ncbi.nlm.nih.gov/29581580/

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• Stemness and anti-cancer drug resistance in ATP-binding cassette subfamily G member 2 highly expressed pancreatic cancer is induced in 3D culture conditions. Norihiko Sasaki, Toshiyuki Ishiwata, Fumio Hasegawa, Masaki Michishita, Hiroki Kawai, Yoko Matsuda, Tomio Arai, Noshi Ishikawa, Junko Aida, Kaiyo Takubo, Masashi Toyoda. Cancer Science 2018 Apr;109(4):1135-1146. doi: 10.1111/cas.13533.   Cancer Sci. 2018 Apr;109(4):1135-1146. doi: 10.1111/cas.13533.

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• Electron microscopic analysis of different cell types in human pancreatic cancer spheres. Toshiyuki Ishiwata, Fumio Hasegawa, Masaki Michishita, Norihiko Sasaki, Naoshi Ishikawa, Kaiyo Takubo, Yoko Matsuda, Tomio Arai, Junko Aida. Oncol Lett. 2018 Feb;15(2):2485-2490. doi: 10.3892/ol.2017.7554.

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