がん幹細胞研究
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Sasaki N, Hirabayashi K, Michishita M, Takahashi K, Hasegawa F, Gomi F, Itakura Y, Nakamura N, Toyoda M, ★Ishiwata T. Ganglioside GM2, highly expressed in the MIA PaCa-2 pancreatic ductal adenocarcinoma cell line, is correlated with growth, invasion, and advanced stage. Sci Rep. 2019 Dec 18;9(1):19369.
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Enhanced morphological and functional differences of pancreatic cancer with epithelial or mesenchymal characteristics in 3D culture. Shichi Y*, Sasaki N*, Michishita M, Hasegawa F, Matsuda Y, Arai T, Gomi F, Aida F, Takubo T, Toyoda M, Yoshimura H, Takahashi K, Ishiwata T. *co-first author. Sci Rep. 2019 Jul 26;9(1):10871. doi:10.1038/s41598-019-47416-w. PubMed PMID: 31350453; PubMed Central PMCID: PMC6659675.
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Fetal bovine serum enlarges the size of human pancreatic cancer spheres accompanied by an increase in the expression of cancer stem cell markers. Sasaki N, Toyoda M, Hasegawa F, Fujiwara M, Gomi F, Ishiwata T. Biochem Biophys Res Commun. 2019 Jun 18; 514 (1): 112-117,doi: 10.1016/j.bbrc.2019.04.117.
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Sasaki N, Itakura Y, Gomi F, Hirano K, Toyoda M, Ishiwata T. Comparison of functional glycans between cancer stem cells and normal stem cells. Histol Histopathol. 2019 Apr 26:18119. doi: 10.14670/HH-18-119.
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Ishiwata T, Matsuda Y, Yoshimura H, Sasaki N, Ishiwata S, Ishikawa N, Takubo K, Arai T, Aida J. Pancreatic cancer stem cells: features and detection methods. Pathol Oncol Res. 2018 Oct;24(4):797-805. doi: 10.1007/s12253-018-0420-x. Epub 2018 Jun 8. Review. PubMed PMID: 29948612.
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H19 long non-coding RNA contributes to sphere formation and invasion through regulation of CD24 and integrin expression in pancreatic cancer cells. Sasaki N, Toyoda M, Yoshimura H, Matsuda Y, Arai T, Takubo K, Aida J, Ishiwata T. Oncotarget. 2018 Oct 5;9(78):34719-34734. doi: 10.18632/oncotarget.26176.
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Reduced expression of the H19 long non-coding RNA inhibits pancreatic cancer metastasis. Yoshimura H, Matsuda Y, Yamamoto M, Michishita M, Takahashi K, Sasaki N, Ishikawa N, Aida J, Takubo K, Arai T, Ishiwata T. Lab Invest. 2018 Jun;98(6):814-824. doi: 10.1038/s41374-018-0048-1.
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Stemness and anti-cancer drug resistance in ATP-binding cassette subfamily G member 2 highly expressed pancreatic cancer is induced in 3D culture conditions. Sasaki N, Ishiwata T, Hasegawa F, Michishita M, Kawai H, Matsuda Y, Arai T, Ishikawa N, Aida J, Takubo K, Toyoda M. Cancer Sci. 2018 Apr;109(4):1135-1146. doi: 10.1111/cas.13533.
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Electron microscopic analysis of different cell types in human pancreatic cancer spheres. Ishiwata T, Hasegawa F, Michishita M, Sasaki N, Ishikawa N, Takubo K, Matsuda Y, Arai T, Aida J. Oncol Lett. 2018 Feb;15(2):2485-2490. doi: 10.3892/ol.2017.7554.
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